What is THCPO and what are its effects?

17. 04. 2024

What is THCPO?

THCPO (THCP-O), or tetrahydrocannabiphorol acetate, is a modified form of the cannabinoid THCP to which an acetate group ('O') has been added in a chemical reaction called acylation. It is a semi-synthetic cannabinoid. While its precursor THCP can be extracted directly from the cannabis plant, THCPO is only produced in the laboratory. 

THCPO was first synthesised in 2021. Due to a modification of its chemical structure, it has a higher thermal and oxidative stability and therefore a longer lifetime than THCP. Both of these cannabinoids have a side chain of seven carbons, unlike the better-known psychoactive cannabinoid THC, which has only a five-carbon alkyl chain.

What are the effects of THCPO?

THCPO is more potent than THCP because of the added acetate group. A 2019 scientific study found that THCP exhibits up to 33 times more activity at CB1 receptors in the endocannabinoid system than delta-9 THC. THCPO also has a high affinity for CB1 receptors in the brain, and therefore strong psychoactive effects. 

It is speculated that THCPO could be as much as 30 times more potent than delta-9 THC. Although this is more of a guess than scientifically based information, what is certain is that THCPO is not for beginners and that it can take even experienced cannabis users by surprise. 

THCPO can induce strong euphoric feelings, intoxication, relaxation or drowsiness. The effects can reportedly last up to eight hours, which is considerably longer than most other cannabinoids.

It should be stressed that there are no studies on THCPO yet. The evaluation of the effects of this substance is therefore based mainly on the experience of users themselves and on information on other cannabinoids that have undergone the same chemical treatment (THC-O, HHC-O).  

 

Side effects of THCPO?

The side effects of THCPO are expected to be the same as for other psychoactive cannabinoids. These include:

• red eyes
• dry mouth
• paranoia
• anxiety
• drowsiness

These side effects are short-term, which means they should subside within a few hours. We know nothing about the long-term effects of THCPO on the body and mind due to the lack of research.

THCPO products

The product range currently consists mainly of vapes and cartridges. Most of these products contain other cannabinoids in addition to THCPO, such as HHC-P or THCP. CBD flowers infused with THCPO distillate, THCPO hash and gummies are also available on the market.

It is very likely that THCPO will soon be available here. In this case, the same applies as with other new cannabinoids, especially those with strong effects - start very carefully, i.e. with a low dose, and only buy from reputable sellers who have their goods laboratory tested. Keep in mind that there are no scientific studies to confirm the effects and safety of THCPO, so there are possible health risks associated with the use of these substances.