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What is H4CBD?

What is H4CBD?

H4CBD is a cannabinoid that was created by synthetically modifying CBD. This cannabinoid is a hexahydroderivative of CBD, which means that four hydrogen atoms have been added to the CBD molecule. How is H4CBD produced? Simply put, we can liken the production process to the way margarine is made from vegetable oil.

H4CBD or THD is a derivative of CBD that is produced in the laboratory or semi-synthetically. Also known as hydrogenated CBD, this cannabinoid was created as an alternative form of conventional CBD. Scientists have been researching and developing semi-synthetic and synthetic cannabinoids since the mid-20th century.

How does H4CBD work?

H4CBD is still "in its infancy", i.e. it remains a relatively unexplored cannabinoid, but the few information about it suggests that it has an affinity for CB1 neuroreceptors.

H4CBD is actually a modified version of CBD, but with the difference that it affects the mind. The effects are similar to HHC, but H4CBD does not contain a double bond. H4CBD is made up of two diastereomers, R and S, with the R diastereomer having noticeably stronger effects than the S diastereomer.

Users of H4CBD have described their experience by comparing the effects to CBD, but have reported experiencing psychoactive effects in addition.

Is H4CBD the same as CBD?

The answer is, "No, it's not." Although the two cannabinoids share some properties, they are different molecules. For example, they have completely different effects, and the fundamental differences lie in their chemical structures and methods of production.

What is the comparison between H4CBD and HHC?

H4CBD and HHC are different substances, although their origin is similar. HHC is the hydrogenated version of THC, whereas H4CBD is the hydrogenated version of CBD. Each is based on different basic molecules. This difference also results in different effects on the body.

Big comparison: H4CBD vs. CBD

CBD and H4CBD have a lot in common, but they also differ in many ways. How do these two cannabinoids compare? Take a look at the following categories.

Source

Both CBD and H4CBD come from hemp. CBD is a direct derivative of hemp, whereas H4CBD undergoes a transformation process, including hydrogenation, to reach its final form.

Because of this, H4CBD is considered a synthetic cannabinoid, even though it is only synthetic as margarine. Technically, it is also possible to synthesize CBD. However, there is no reason to do so, as this cannabinoid is abundant in cannabis.

 

Laboratory environment with cannabis leaf, vial with H4CBD distillate

 

Structure

H4CBD has been structurally modified to take on a different form than CBD. This is a chemical process that inserts hydrogen atoms into the selected molecule. Four additional hydrogen atoms, are added to the molecule, altering its natural properties.

Effects of H4CBD

If we look at a single study from 2006, we find that the study says that hydrogenated forms of CBD have an extremely high affinity for the brain's CB1 neuroreceptors. It is this finding that has expanded speculation that H4CBD may have effects up to a hundred times greater than CBD - at least in some ways.

A review of research from 2017 confirmed this assumption, but no new studies on the bioactive properties of H4CBD have been conducted.

Potential

H4CBD could provide users with something in the range of three times the potency of CBD. H4CBD is reported to offer 100 times the potency of regular CBD. However, we've already learned that even if this is the case, it only applies to the potency of CBD on CB1 receptors. And this efficacy was initially negligible for CBD.

H4CBD at CB1 receptors requires further investigation to draw any conclusions related to potential increased activity.

So calling out to the world that H4CBD is "100 times more potent" than CBD in all areas is a rather exaggerated claim.

Legality of H4CBD in the Czech Republic

The legality of synthetic and natural cannabinoids is currently the subject of much controversy. Government Regulation No. 463/2013 Coll., on the lists of addictive substances, defines what constitutes an "intoxicating substance":

  • Cannabis extract and tincture. With the exception of the substance cannabis extract and tincture, which contains 1 % of substances of the tetrahydrocannabinol group and meets the safety condition of the General Product Safety Act
  • Cannabis
  • Cannabis resin
  • Tetrahydrocannabinol (THC): ?6a(10a)-, ?6?(7)-, ?7-, ?8-, ?10-, ?9(11)-tetrahydrocannabinols and their stereoisomers

Currently, H4CBD is not on the list of addictive substances.

What is the availability of H4CBD?

CBD is currently one of the most readily available cannabinoids. However, the demand for H4CBD is growing rapidly and this will naturally lead to the development of a wider range of products. High-quality distillates, isolates and finished H4CBD products are slowly appearing on the internet, heralding the birth of a whole new era of cannabis.

How to choose the best H4CBD power supply?

H4CBD is hot news, so it is imperative that every user find a product source that has been on the market for some time. The right H4CBD manufacturer is very well established in the market and boasts an excellent reputation and its products own certification.

Could it be that H4CBD will compete with CBD in the market?

H4CBD has come to the attention of scientists since the 1940s. However, it is only recently that this hydrogenated form of CBD has started to make a splash. It is therefore likely that demand for alternatives that could offer even better benefits will rise along with it.

Could it be that H4CBD will compete with CBD in the market? That's a pretty interesting question, but it probably won't be enough to completely displace CBD from the market. CBD is very popular and widely used, so it will still dominate the market as one of the main options. However, if H4CBD does indeed abound with specific benefits over CBD, it may earn its reputation in the market and find customers looking for the specific qualities that H4CBD provides.

Ultimately, it will be up to consumers to decide what choices to make and to manufacturers to offer products.

H4CBD can be seen as a finely-tuned alternative with higher potency, whereas CBD offers a natural variant with lower potency. As modern cannabinoid medicine continues to evolve, both CBD and H4CBD will undoubtedly play a key role.

 

Cannabis leaves and top view of H4CBD distillate in a glass container

You might be interested in: What are the most common questions about H4CBD?

Still feel like you don't know enough? Do you want to know more? Check out the H4CBD FAQs.

1. What are hydrogenated cannabinoids?

Cannabinoids can undergo the process of hydrogenation, which involves adding hydrogen atoms to the molecules. A hydrogenated cannabinoid is therefore a cannabinoid that has undergone hydrogenation. This process can be applied to many different cannabinoids and different numbers of hydrogen atoms can be added. Each hydrogenated cannabinoid has its own specific properties, but in general the chemical hydrogenation of cannabinoids often results in an increase in potency.

2. Is H4CBD synthetic?

Yes, H4CBD is basically a synthetic cannabinoid. Although it was derived from a natural cannabinoid, it has been modified to give it new and unique properties. Although H4CBD is not entirely man-made, any tampering with a natural compound is generally considered a synthetic modification of the original substance.

3. Is H4CBD 100 times more potent than CBD?

It is important to note that the claim that H4CBD is hundreds of times more potent than conventional CBD is based on speculation rather than real facts. There is only one study that is over 15 years old that suggests that H4CBD could have a significantly higher affinity for CB1 nervous system receptors compared to CBD. However, these receptors are not the main target of conventional CBD and such speculation may therefore be more scientific hype than reality.

Normally, CBD has very little affinity for CB1 and may even reduce its activity. However, when combined with four hydrogen atoms, the affinity of CBD for CB1 is obviously increased, making the new cannabinoid (H4CBD) more psychoactive.

4. Does H4CBD cause "highs"?

It certainly cannot be said that H4CBD causes highs. However, this cannabinoid also does not provide the effects we usually associate with CBD. The effects of taking H4CBD appear to be similar to those of taking large doses of CBD, but we must bear in mind that this information is based on limited preliminary research and anecdotal evidence.

H4CBD can induce a feeling of relaxation and euphoria that can help relieve stress without causing a significant high.

5. Is H4CBD the same as HHC?

No, H4CBD and HHC are distinct, but in the context of their origins it is natural that the two cannabinoids may be confused. Just as H4CBD is the hydrogenated form of CBD, HHC is the hydrogenated form of THC.

6. Are there strains with H4CBD?

H4CBD is not found in nature. This means that there are no strains of cannabis or hemp containing H4CBD. Since it is not possible to extract natural H4CBD, this cannabinoid can only be produced by hydrogenation.

7. What is the best type of H4CBD product?

Users generally prefer H4CBD vapes and gummies. Over time, capsules, tablets, and even topical H4CBD preparations can also be expected to come to the fore. Whatever the product type, H4CBD products should contain simple ingredients and be accompanied by thorough lab reports.

8. What are some common effects of H4CBD?

Given what little we now know, H4CBD appears to have roughly identical effects to CBD. However, some evidence suggests that this synthetic CBD derivative may be more potent on certain neuroreceptors. In the context of the continuing lack of research, not enough is known about H4CBD to say anything definitive about its effects.

9. What is the H4CBD distillate?

The H4CBD distillate consists of H4CBD grouped with a 'denatured' cannabis distillate from which the other cannabinoids have been removed. Rare cannabinoids such as H4CBD are mainly available in distillate form. This is because it is easy to combine the distillate base with virtually any isolated cannabinoid.

Like most cannabinoids other than CBD and CBG, H4CBD must be produced as a derivative of a natural cannabinoid from hemp, and this makes H4CBD distillate an inherently synthetic product. Even though the synthetic cannabinoid dominates the distillate, H4CBD still looks as you might suspect - typically honey-coloured, viscous and transparent.

10. What is the difference between CBD and H4CBD?

CBD and H4CBD differ significantly not only in that CBD is natural while H4CBD is synthetic, but also in many other aspects that scientists are still thinking about and researching. Although interest in both cannabinoids has increased significantly in recent years, there are still many properties and effects that need to be explored.

11. H4CBD gummies vs. H4CBD tinctures

H4CBD tinctures are simple and natural, whereas H4CBD gummies may taste better or be easier to use. Given that new cannabinoids are still relatively new discoveries, the availability of quality products is limited at the moment.

 

Author: Canatura

   

   

Photo: Shutterstock

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