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What is CBG9 and what are its origins and effects?

What is CBG9 and what is its origin?

It is reported that CBG9 is a variant of cannabigerol (CBG) and that it is the so-called chemical precursor from which other cannabinoids such as THC and CBD, the two most well-known components of the cannabis plant, are developed.

The name CBG9 according to IUPAC (The International Union of Pure and Applied Chemistry) is 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol.

CBG9 stands for cannabigerol-9. The number 9 in the name indicates a specific variant - it differs from the parent compound in chemical structure and/or properties.

There are many questions surrounding CBG9 at the moment, some believe that it is a phytocannabinoid found naturally in the cannabis plant and that it is possible to extract CBG9 directly from the plant. Others, however, dispute this and claim that it is a compound that is created in the laboratory from other available precursors, hence the (semi)synthetic cannabinoid label.

All we know so far is that CBG9, unlike other cannabinoids, does not crystallise and may therefore be less prone to degradation and have a longer shelf life. Since it does not form crystals, it is easier to process and, given its liquid, non-crystallised form, it could have a higher bioavailability. CB9, which is a derivative of CBD, has the same property (non-crystallising).

We'd love to reveal more about the origins and structure of CBG9, but at the moment it looks like the manufacturers are keeping their secrets to themselves. If CBG9 were to be found in the cannabis plant, it would be similar to other minor cannabinoids such as THCJD, THCB, delta-8-THC, THCP and THCH, which, although found in the plant, are more likely to be produced synthetically because it is virtually impossible to extract them directly from the cannabis plant in quantities that would satisfy commercial demand.

Typically, most of these products are made from other, more readily available cannabinoids such as CBD.

To further explore what effects CBG9 offers, let's talk about CBG (cannabigerol).

We know more about CBG...

CBG is one of the many cannabinoid compounds in the cannabis plant. This cannabinoid has even been nicknamed "the mother of all cannabinoids". That's because without CBG, neither THC nor CBD would exist. In fact, CBG is the first cannabinoid that the cannabis plant produces at the germination stage.

All cannabinoids start out as CBGa before breaking down into THCa, CBDa, CBCa. In the final stage, these acidic forms of cannabinoids are converted by heat or ultraviolet light into THC, CBD, CBC and others.

Since CBGa is converted into other cannabinoids, fully grown mature cannabis plants contain only a modest concentration of cannabigerol. Therefore, CBG is not as renowned or as readily available as CBD.


Infographics showing the cannabis leaf and cannabinoids such as CBG, THC, THCV, CBC, CBN and CBD

What are the effects of CBG?

Both CBD and CBG interact with cannabinoid receptors in the endocannabinoid system (ECS). This system plays a key role in the regulation of various physiological processes, including mood, sleep, immunity and stress response. Both of these compounds are non-psychoactive and contribute to overall well-being. They are often used to relieve symptoms of pain, sleep difficulties or to combat stress.

CBG interacts with the ECS by partial activation of CB1 and CB2 receptors. According to one study, it could thus affect sleep, mood and appetite in a similar way to CBD, and could also stimulate receptors responsible for pain and heat sensitivity. Unlike CBD, CBG binds better to both CB1 receptors (found mainly in the brain) and CB2 receptors and integrates with specific receptors.

CBG shows promising therapeutic benefits according to the studies conducted so far. Although research on CBG is just beginning, experts have already assigned the following properties to the compound:

  • Antibacterial
  • Antifungal
  • Antiparasitic
  • Neuroprotective
  • arousing taste
  • reducing bladder contractions (positive effect of CBG on urinary tract problems)
  • dermatological (soothing effect for the skin)

The study suggested that CBG could be a promising substance that inhibits the growth of cancer cells such as colon cancer and glioblastoma. Another study suggested that it reduces intraocular pressure glaucoma.

One study reported that CBG shows the ability to reduce inflammation. A 2022 study suggested that acute administration of CBG lowers blood pressure in mice.

Studies in rodents found that cannabigerol stimulated the appetite of some mice and caused them to eat up to 2 times more food than usual, while others showed no change.


Infographic showing the potential therapeutic benefits of CBG

How does CBG9 work in the body?

CBG9 differs from other cannabinoids because of its unique chemical structure and how it works in the human body. If you're wondering exactly how it works, you may be disappointed, as CBG9's interaction with the ECS is still under investigation. It is reported that CBG9 is not psychoactive, but there is a lack of relevant data to confirm this information.

Potential therapeutic properties of CBG9

Experience suggests that derivatives of cannabinoids usually have a similar type of effect to their original compounds (precursors), but higher potency. (For example, the hydrogenated version of CBD, the cannabinoid H4CBD, is referred to as a 'boosted' form of cannabidiol.) Based on this hypothesis, the effects of CBG9 are expected to be similar to those of CBG, but are likely to be more intense.

On this basis, it can be assumed that CBG9 could have mainly the following characteristics:

  • Anti-inflammatory
  • Antibacterial
  • Analgesic
  • Neuroprotective

It must be added that for now this is only speculation, based mainly on the characteristics of CBG. Now we can only wait to see how the research that will confirm/refute the potential benefits of CBG9 progresses.

Effects of CBG9: What do the experiences and reviews from the Internet say?

There are a few experiences with CBG9 on Reddit. One user wrote that CBG9 felt like a psychedelic version of CBG. Uplifting, energizing with a slight "stoned" feeling.

Another user said that he felt no effects after taking CBG9 gummies, and with pre-rolls it felt like smoking large amounts of leaves from regular cannabis.

Side effects of CBG9 and other risks

There is also currently no research on CBG9 that looks at possible side effects. Thus, most information on these effects comes from anecdotal reports or studies with related cannabinoids.

Research to date shows that CBG is very well tolerated, similar to CBD. However, further studies are needed to confirm this information. Possible side effects of CBD and CBG include nausea, fatigue, dry mouth or diarrhoea. At the moment, it cannot be ruled out that other as yet unknown side effects will not occur with CBG9.

The intensity of these effects will depend on several factors, such as health status, body proportions, immunity, sensitivity, tolerance, age, health status, efficacy of the product and others.

Experts agree that natural cannabinoids are safe for medical and recreational use, while (semi)synthetic cannabinoids, on the other hand, often cannot be proven to be pure and safe.

In general, (semi)synthetic compounds can be much more potent than natural ones, increasing the potential risk of intoxication and overdose, which can result in a "bad trip".  Some users may experience negative psychological effects, especially anxiety, panic, paranoia and hallucinations.

Available products CBG9

Although CBG9 products are readily available, it is still the case that there is currently no research looking at the effects or how this substance works in the body.

CBG9 is most commonly found in the cannabis market in the following forms:

  • Oils: CBG9 "extract" with carrier oil
  • Vapes: vape pens can be used right away and can be purchased as disposables or refillable devices with liquid or replaceable cartridges.
  • Cartridge: pre-filled cartridges with CBG9 distillate
  • CBG9 flowers: technical cannabis flowers infused with CBG9 distillate
  • Pre-rolls: pre-packaged joint containing CBG9 flowers
  • Dabs: concentrated forms of cannabis or concentrates, such as hash, which are inhaled through a vaporizer or dab rig.
  • Edibles: for example, snacks and gummies infused with CBG9 spirit

If you decide to buy any cannabis product, always request an independent laboratory analysis to find out the composition of the product and whether it contains any unsuitable additives, fillers and toxins. Choose trusted and vetted companies.

The third-party lab report provides information on the composition, purity of the product and whether the THC limit is exceeded. In the Czech Republic, the maximum THC limit is 1 %, in Europe it is 0,2-0,3 % THC on a dry basis.


CBG9 products, dark dropper bottles with CBG9 oil, CBG9 technical cannabis capsules and sticks

Conclusion: is CBG9 safe?

Cannabigerol-9 is reportedly a derivative of CBG. Opinions differ as to whether or not it is present in cannabis. If CBG9 is present in cannabis, it is likely to be present in only minute quantities, meaning that it will be produced in a similar way to other minor cannabinoids from more readily available precursors such as CBD. This is why it is labelled a (semi)synthetic cannabinoid.

At present, information on the effects and possible therapeutic potential is mainly based on CBG. There are no studies available that address how CBG9 works and whether the products are safe. In particular, due to the lack of clinical studies, it cannot yet be stated with certainty that the use of CBG9 is completely risk-free.

The situation is complicated by the fact that there is complex legislation on cannabinoids across the world. As it stands at the moment, until CBG9 and other cannabis derivatives are regulated, users must assess the potential risks and benefits of these compounds for themselves.

CBG9 is now an authorised substance in most parts of Europe, or it may be in a legal grey area.

Approach similar compounds with discretion and respect. It is not recommended to drive or operate any machinery after use.


Author: Canatura



Photo: Shutterstock

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