CBNO: An unknown cannabinoid with great potential
When the cannabis industry talks about CBNO, it usually does not spare praise. And it should be noted that it is well deserved. The unique cannabinoid differs from well-known compounds such as CBD and CBG not only in its chemical composition but also in the breadth of its potential.
What is CBNO?
As you may have guessed, CBN-O, short for cannabinol acetate-O, is an acetylated version of CBN. In layman's terms, CBNO is a chemically modified form of CBN. As it happens, on a molecular level this version differs little from its base version, CBN, but enough to induce a whole host of new effects.
CBNO vs. CBN
Before going into a detailed comparison, recall that CBN is a cannabinoid that is formed by degradation of THC, while CBNO is a derivative of CBN that is formed by oxidation.
CBNO shares a number of features with CBN:
- both compounds are non-psychoactive
- have some potential effects in common (e.g. effect on sleep)
- are legal in most countries and are not internationally listed as dangerous substances (CBNO is a newcomer to cannabinoids and therefore may not yet be directly regulated by some jurisdictions, but merely falls under the legal definition of "cannabinoid").
- can be found in a wide range of products
And how are they different? Apart from the fact that they are formed in a different way, the main difference between CBNO and CBN lies in the degree of effectiveness. It is believed that the change in chemical structure, where CBN is oxidised to CBNO, makes CBNO several times more potent than its counterpart.
Some sources report that CBNO is almost three times more potent than regular CBN.
What are the effects of CBNO?
As it is a relatively new cannabinoid, it has not yet been thoroughly investigated by the scientific community. No studies or validated information on the specific effects of CBNO are yet available in the literature.
But while research into the effects of CBNO is still in its infancy, there are already promising signs of possible future health applications.
As with other cannabinoids, the interaction of CBNO with the endocannabinoid system of the human body and its possible therapeutic and other uses will most likely be the focus of research in the coming years.
This system plays an important role in the regulation of physiological processes, including:
- pain perception
- Immunity
- appetite
- sleep and mood
Findings to date show that CBNO has a weaker binding to the CB1 receptor, which is abundant in the central nervous system and is associated with the psychoactive effects of THC. Conversely, it has a stronger binding to the CB2 receptor, which is more closely associated with the immune system and has a limited effect on the central nervous system. The bottom line is that these characteristics result in less or no psychoactive effects of CBNO and its greater potential for therapeutic use.
While research on CBNO is at an early stage, there is more information on the related cannabinoid CBN to draw on.
In general, CBNO, based on knowledge of CBN (and other cannabinoids) and user experience, could have the potential to reduce inflammation, relieve pain, help with stress and tension, promote sleep and protect cells from degradation.
Anti-inflammatory potential
Some cannabinoids, including CBN and, hypothetically, CBNO, have been attributed anti-inflammatory properties that could be used to treat chronic inflammatory diseases and similar health problems. One well-known animal study, for example, found that CBN could be an effective anti-inflammatory agent in the fight against arthritis.
Pain relief
Research suggests that many cannabinoids have potential analgesic effects. Of note is a review study published in 2015 in the prestigious medical journal JAMA. This analysis pooled results from 79 clinical trials and found that cannabinoids may be effective in reducing both chronic and, especially, neuropathic pain.
Promising results came from a 2019 study investigating whether CBN, CBD and CBC, or a combination of them, reduce muscle sensitization in female rats. According to the researchers, CBN could provide pain relief for chronic muscle pain disorders such as temporomandibular disorders (pain in jaw muscles, joints and nerves) and fibromyalgia (pain syndrome throughout the body), without adverse side effects. However, clinical studies have not yet verified this theory.
Therapeutic effects
Potential relaxing and calming effects, such as stress relief or anxiety reduction, go hand in hand with cannabinoids, according to users and the scientific community. CBNO is unlikely to be an exception due to its specific properties, but we will have to wait some time for concrete results. CBNO oils and drops, for example, can be helpful for stress and tension.
Sleep support
Insomnia is the most prevalent sleep disorder for which there are few effective drugs. In recent years, the cannabinoids CBD and CBN have gained the most attention, and their possible effects on sleep quality and the possibility of regulating sleep are being investigated. In one recent study, CBN was shown to both help speed up the process of falling asleep and, secondarily, to help the body stay in a deep sleep phase.
CBNO, and especially CBNO isolate (the purest form of CBNO on the market), can act as a mild sedative similar to CBN, making it an excellent choice for people struggling with sleep disorders. On the plus side, the isolates allow for precise dosing and can be easily added to existing formulations of other products.
Neuroprotection
In neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease or multiple sclerosis, cannabinoids may have neuroprotective effects, according to existing research. This means that they can protect neurons or nerve cells from degradation.
Particularly promising are the conclusions about CBN that scientists from the Laboratory of Molecular and Cell Biology at the Salk Institute have reached in 2022. According to their findings, CBN protects neurons from oxidative stress and cell death, two major factors that contribute to Alzheimer's disease. They also expressed the belief that this discovery could lead to new ways to treat this and similar age-related diseases.
And how will a stronger CBNO shuffle the cards? Let's be surprised.
CBNO products
CBNO offers versatile ways of eating. The choice depends on personal preferences and desired effects.
Inhalation
For example, cartridges with the popular flavours White Cherry/Gelato and Jack the Ripper guarantee a unique taste experience. Both cartridges contain 50% CBNO. If you're looking for a simple, convenient yet authentic experience, CBNO prerolls are the right choice for you. Also worth checking out are CBNO liquids designed for vaping in electronic cigarettes and disposable vaporizers with CBNO.
For users looking for alternative ways to consume cannabinoids, CBNO-enriched hashish may be a suitable option. You won't go wrong with CBNO-infused Raspberry Kush cannabis flowers either. When vaping, you will especially appreciate the sweet, fruity aroma reminiscent of raspberries.
For those who prefer pure and concentrated forms of cannabinoids without additional additives and flavours, CBNO distillates are ideal. They are often used as base ingredients for the production of other CBNO products such as vaporizers or oils and drops. The advantage over other products is also more precise dosing.
Nutrients
CBNO gummies with different fruit flavours can be a way to indulge in something sweet and try CBNO at the same time. For example, we offer CBNO Fruit Gummies mix from Canntropy with 10 mg of CBNO in one piece, for a total of 100 mg of CBNO per whole pack.
THC is present in CBNO gummies at less than 0.2%, which is the legal limit in most European countries.
Conclusion
CBNO is a relatively new and not yet well-studied cannabinoid. It is formed through the chemical oxidation of CBN and is reported to be up to three times more potent than CBN.
Although CBNO research is in its infancy, it is believed that this cannabinoid could have anti-inflammatory, analgesic, neuroprotective and therapeutic effects. Its role in sleep disorders will also be investigated in the future. CBNO can be found in a wide range of products from oils and drops to cartridges and liquids to edibles.
Author: Canatura
Photo: AI
"All information provided on this website, as well as information provided through this website, is for educational purposes only. None of the information contained herein is intended to be a substitute for a medical diagnosis and should not be considered medical advice or recommended treatment. This website does not endorse, condones or advocate the licit or illicit use of narcotic drugs or psychotropic substances or the commission of any other illegal activity. For more information, please see our Disclaimer ."